Welcome to MetaDome

MetaDome analyses the mutation tolerance at each position in a human protein. It uses data from gnomAD and ClinVar. MetaDome enhances the analysis of your gene of interest by parallel analysis of all homologous domains in the whole human genome.

Input your gene name and pick your transcript and MetaDome will collect and combine available information to produce a tolerance landscape, annotate Pfam domains and pathogenic ClinVar variants, and provide meta-domain variant annotation. Complete with results, ability to edit and download all the information.

You can edit, print, and download the results. MetaDome usage is free, but we hope you faithfully cite our articles.